Model NO.: 104987-11-3 Customized: Non-Customized State: Solid Storage: Dry and Ban on Damp Shief Time: 2 Years Mf: C44h69no12 MOQ: 1kg Trademark: DAHUA Origin: China Powder: Yes Certification: ISO 9001, USP, BP Purity: >99% Transportation: by EMS, DHL, UPS, or FedEx Delivery Time: 3 Days MW: 804.02 Einecs: 208-633-6 Specification: CP HS Code: 12345678 Tacrolimus 99% High Purity Factory Supplying Cas: 104987-11-3 Basic Info Model NO.: 104987-11-3 Customized: Non-Customized Suitable for: Adult Purity: >99% Molecular Formula: C44h69no12 Assay: 99% Delivery Time: Within 24 Hours Upon Receipt of Payment Grade: Pharmaceutical Grade Express: UPS,TNT,DHL,EMS,Hkems,FedEx Specification: ISO9001, GMP HS Code: 29152990 Powder: Yes Certification: ISO 9001 State: Solid CAS: 104987-11-3 Molecular Weight: 804.02 Appearance: White Crystalline Solid Payment: Western Union, Money Gram, T/T Export Markets: Global Trademark: Dahua Origin: Shenzhne, China Product Description
Tacrolimus 99% High Purity Factory Supplying CAS 104987-11-3
Product Categories:Pharmaceuticals;Chiral Reagents;Fujimycin, Prograf;antibiotic
Chemical Properties: White Crystalline Solid
Usage: An immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release.
Packing:foil bag or tin
Place of origin:China
Price terms:Western union, moneygram, t/t,Bitcoin
Delivery lead time:Within 24 hours after payment
Transportation:By ems, dhl, ups, or fedex
heart liver kidney and bone marrow transplant patients preferred immune-suppressing drugs after the transplant rejection resistant to conventional immunosuppressive regimen, is also the choice of the drug... Adverse reactions similar to cyclosporine. autoimmune eye disease and other autoimmune diseases also play an active role.
It has similar immunosuppressive properties to ciclosporin, but is much more potent. Immunosuppression with tacrolimus was associated with a significantly lower rate of acute rejection compared with ciclosporin-based immunosuppression (30.7% vs 46.4%) in one study. Clinical outcome is better with tacrolimus than with ciclosporin during the first year of liver transplantation. Long term outcome has not been improved to the same extent. Tacrolimus is normally prescribed as part of a post-transplant cocktail including steroids, mycophenolate and IL-2 receptor inhibitors. Dosages are titrated to target blood levels. Typical starting doses for once daily tacrolimus are 0.15-0.20 mg/kg body weight.
Also like cyclosporin it has a wide range of interactions, including that with grapefruit which increases plasma-tacrolimus concentration. Several of the newer class of antifungals, especially of the azole class (fluconazole, posaconazole) also increase drug levels by competing for degradative enzymes.
In recent years, tacrolimus has been used to suppress the inflammation associated with ulcerative colitis, a form of inflammatory bowel disease. Although almost exclusively used in trial cases only, tacrolimus has shown to be significantly effective in the suppression of outbreaks of UC.
As an ointment, tacrolimus is used in the treatment of eczema, in particular atopic dermatitis. It suppresses inflammation in a similar way to steroids, and is equally as effective as a mid-potency steroid. An important advantage of tacrolimus is that, unlike steroids, it does not cause skin thinning (atrophy), or other steroid related side-effects.
It is applied on the active lesions until they heal off, but may also be used continuously in low doses (twice a week), and applied to the thinner skin over the face and eyelids. Clinical trials of up to one year have been conducted. Recently it has also been used to treat segmental vitiligo in children, especially in areas on the face
|Test ||Specification ||Result |
|Description ||A white crystalline powder ||Complies |
|Solubility ||Soluble in Methanol, Ethyl acetate and Chloroform ||Complies |
|Water ||≤3.0% ||1.3% |
|Residue on ignition ||≤0.10% ||Complies |
|Heavy metals ||<10ppm ||Complies |
|Isomer ||≤5.0% ||0.56% |
| Individual Impurity |
|≤0.5% ||0.33% |
|T otalimpurities ||≤2.0% ||0.43% |
| Assay ( on dry basis |
|≥98.0% ||99.8% |
|Conclusion ||The product conforms to the Enterprise specification. |
Function of Tacrolimus:
Used for organ transplant anti - rejection reaction, especially suitable for liver transplantation, can also be used for the kidney, heart, lung, pancreas, bone marrow and corneal transplantation.
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