Pazopanib Purity 99% CAS No 444731-52-6 of Pazopanib

Model NO.: 444731-52-6 Customized: Non-Customized Suitable for: Adult Purity: >99% Molecular Formula: C21h24cln7o2s Transport Package: According to Customer′s Requirements Origin: China Powder: Yes Certification: GMP, ISO 9001 State: Powder Molecular Weight : 473.9 Trademark: Dahua Specification: USP/BP, EP HS Code: 3001200020 Hot Sell Small Molecular API Pazopanib Hydrochloride (CAS No.: 635702-64-6)



Product Name    Pazopanib Hydrochloride
Molecular Formula    C21H24ClN7O2S
Molecular Weight    473.98
CAS No.: 635702-64-6

Pazopanib HCl (GW786034 HCl) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, respectively.
Pazopanib potently inhibits VEGF-induced phosphorylation of VEGFR2 in HUVEC cells with IC50 of 8 nM. Pazopanib shows dose-dependent growth inhibition in all synovial sarcoma cell lines including SYO-1 and HS-SY-II cells. Proliferation of SYO-1 and HS-SY-II cells is inhibited even at 1μg/mL of Pazopanib and is completely abolished at 5μg/mL. Pazopanib induces G1 arrest, and thereby suppresses the growth of synovial sarcoma cells. Phosphorylation of Akts, GSK-3β, JNKs, p70 S6 Kinase, and mTOR is suppressed in Pazopanib-treated SYO-1 cells compared with that in the vehicle-treated cells. Pazopanib between 20 m g/mL and 22.5 m g/mL shows an increasing reduction of RPE cell viability.The mice treated with 30 mg/kg or 100mg/kg Pazopanib reveals a significant decrease in tumor burden compared with the mice treated with vehicle or 10mg/kg Pazopanib. Treatment with Pazopanib is well-tolerated and there is no significant difference in the body weight among the mice in each group.

Product list	Cas No.
Chloroambucil	305-03-3
Dacarbazine	4342-o3-4
Mitomycin C	50-o7-7
Streptozocin	18883-66-4
Carmustine	154-93-8
Lomustine	13010-47-4
Ifosfamide	3778-73-2
Cyclophosphamide	6055-19-2
Procarbazine HCl	366-70-1
Nimustine HCl(ACNU)	55661-38-6
Cisplatin	15663-27-1
Oxaliplatin	61825-94-3
Carboplatin	41575-94-4
Bleomycin sulfate	9041-93-4
Bleomycin A5 Hydrochloride	55658-47-4
Camptothecin	7689-o3-4
Daunorubicin HCl	23541-50-6
Doxorubicin HCl/Adriamycin	25316-40-9
Epirubicin HCl	56390-09-1
Etoposide	33419-42-0
Irinotecan	97682-44-5
Teniposide	29767-20-2
Topotecan HCl	119413-54-6
Mitoxantrone HCl	70476-82-3
IdarubicinHCl	57852-57-0
Irinotecan HCl	100286-90-6
Azacitidine (5-Azacytidine)	320-67-2
Cytarabine	147-94-4
5-Fluorouracil	51-21-8
Tegafur	17902-23-7
6-TG/Thioguanine	154-42-7
Nelarabine	121032-29-9
Fludarabine Phosphate	75607-67-9
Cladribine	4291-63-8
Methotrexate	59-o5-2
Hydroxyurea/Hydroxycarbamide	127-o7-1
Colchlcine	64-86-8
Docetaxel anhydrous	114977-28-5
Paclitaxel	33069-62-4
Vinorelbine Tartrate	125317-39-7
Vinblastine Sulfate	143-67-9
Anastrozole	120511-73-1
Exemestane	107868-30-4
Letrozole	112809-51-5
Tamoxifen Citrate	54965-24-1
Aminoglutethimide	125-84-8
Megestrol base	3562-63-8
Abiraterone Acetate	154229-18-2
Capecitabine	154361-50-9
Decitabine	2353-33-5
Gemcitabine HCl	122111-03-9

About us: Wuhan Dahua Weiye Pharmaceutical Chemical Co.,Ltd,  a professional raw powder factory in China for over 10 years, all powders are factory directly supplying. Imaginechem can help our worldwide customers shorten the time and lower the cost of drug and medical device Research and Development through cost-effecitve and efficient outsourcing solutions.

 

Packaging & Delivery: 1. Shipping by express (FedEx, UPS, DHL, EMS), by air; By ship. 2. Shipment will be arranged within 24 hours after receiving the payment; 3. Pictures of the package will be sent to you then along with the tracking number; Super discreet packaging, to ensure safe delivery, 99% successful delivery rate is ensured. Delivery time: All of the orders will be packed within 24 hours after we get the payment usually it takes about3~5work days for you to get the parcel. Payment method: Bank wire, Western union, Moneygram 4. How to proceed order: First: Please let me know the itmes you are looking for, quantity, and the destination country. Second: You confirm all details, and offer us purchasing order; Third: We send the detail price of our product and offer the suitable shipping method for reference. Forth: You confirm the order and pay money 100% in advance and send us the detail address. Fifth: We arrange the shipment according to your requirements. Sixth: We offer after-sales service after you receive parcel

 

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